Mifeprex pill contains 200mg Mifepristone, anti-progestational (synthetic steroid) used to terminate an early pregnancy. It blocks hormone (progesterone) required to develop pregnancy. The medicine is only approved to end pregnancy up to first 10 weeks. When you take Mifeprex, you have to consume another medication, Misoprostol, 1 or 3 days later. Only 2 to 5 percent of females may require surgical procedure for ending pregnancy or stopping too much bleeding. The tablets are biconvex/cylindrical and yellow in color, taken orally. It consists of inactive ingredients: corn starch, microcrystalline cellulose, colloidal silica anhydrous, magnesium stearate, and povidone.
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The anti-progesterone activity of the abortion pill results from its interaction with the hormone at the receptor sites. The pregnancy termination results by antagonizing the myometrial and endometrial effect in women. The prostaglandin activity is also contradicted, which breaks away fetus from uterus lining, bringing a stop or nutritional and oxygen supply to the unborn. Cervix begins to widen, and mild contractions are initiated in womb to remove the fetal remains from the uterus.
On the day 1, woman consumes orally 1 Mifeprex tablets of 200mg. The person has to then utilize Misoprostol (800mcg) either in the cheek pouches or vaginally later to 24-48 hours. A combination of both the medication will raise the efficiency of abortion from 95 to 97%. It is not mandatory to take a meal beforehand, but light meal is fine. Avoid smoking, alcohol consumption or overdose.
The woman must understand that during Mifeprex abortion, she may experience mild to moderate abdomen pain and cramps because of uterus contractions.
Women can take Mifeprex for terminating pregnancy, which is in uterus and not outside it. The pregnancy must be within 70 days of gestation. Ultrasonographic scan of womb can assess the gestation age or if the pregnancy is ectopic or otherwise. If an intra-uterine device is there, then the person has to get it removed before taking a treatment with anti-progesterone tablets.
Any consequences from Mifeprex dosage are minimal and disappear quickly after ending of pregnancy. Some side effects women encounters are dizziness, diarrhea, vomiting, nausea, headache, tiredness, abdomen pain etc.
There is no data supporting efficacy of Mifeprex use in females with chronic medical conditions like hepatic, cardiovascular, hypertensive, renal or respiratory disease, severe anemia, diabetes, and heavy smoking.
The serum level of Mifeprex may increase, if it is taken with grapefruit juice or along the course of treatment with itraconazole, erythromycin, or ketoconazole. Mifepristone serum level falls, if it is combined with St. Johns Wort, rifampin, dexamethasone, and anticonvulsants (phenytoin, carbamazepine, or phenobarbital). CYP 3A4 substrates must be avoided.
The Mifeprex abortion pill regimen is not suitable for all. It is contraindicated in women with following conditions: